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淫羊藿传统炮制方法为羊脂油炙,具有增强淫羊藿温肾助阳的作用。该文采用腹腔注射氢化可的松法建立大鼠肾阳虚模型,以大鼠体征,血清睾酮、皮质酮含量,组织病理学检查等为评价指标,研究在辅料羊脂油的作用下,淫羊藿总黄酮在体内自组装形成胶束后对肾阳虚大鼠的增效作用。肾阳虚大鼠灌胃淫羊藿总黄酮和总黄酮胶束后,2组大鼠与模型组相比,体征及各项生化指标趋于正常,下丘脑-垂体-肾上腺-胸腺轴功能紊乱得到有效改善。实验结果表明,淫羊藿总黄酮及其自组装胶束都具有温肾壮阳的作用,其中以炙淫羊藿增强效果为佳。证明在羊脂油作用下,淫羊藿总黄酮可在体内自组装形成胶束,改善下丘脑-垂体-肾上腺-胸腺轴及主要性腺组织睾丸的病理状况,发挥增强淫羊藿温肾助阳的功效,进一步揭示了淫羊藿炮制辅料羊脂油的增效机制。
Traditional Epimedium concocted sunburn oil Sunburn method, with enhanced Epimedium Wenshen help Yang role. In this paper, intraperitoneal injection of hydrocortisone was used to establish the rat model of kidney-yang deficiency, and the signs of rats, serum testosterone, corticosterone content, histopathological examination as the evaluation index, Synergistic Effect of Total Flavonoids in Kidney - Yang Deficiency Rats after Self - assembled into Micelles in. Compared with the model group, the signs and biochemical indexes tended to be normal and the hypothalamus-pituitary-adrenal-thymus axis dysfunction Be effectively improved. The experimental results show that Epimedium total flavonoids and self-assembled micelles have the effect of warming the kidney and invigorating the Yang. Proved in the role of linseed oil, Epimedium Flavonoids in vivo self-assembly to form micelles, to improve the hypothalamus - pituitary - adrenal - thymus axis and major gonadal testicular pathological conditions, to enhance the Epimedium Wenshen help Yang Efficacy, and further revealed Epimedium processing accessories Yangshou You synergistic mechanism.