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目的探讨住院肺结核病人对氧氟沙星的耐药性。方法就１９９３年１月～１９９５年１２月我院住院肺结核病人痰结核菌培养阳性并有药敏结果者２０５例进行了对氧氟沙星耐药性的回顾性调查。结果继发耐药者１１例（１７５％），原发耐药者２例（１４％），通过对氧氟沙星耐药病例的分析，考虑用药时间长及相当于单一用药是氧氟沙星继发耐药产生的原因；而原发耐药的产生，可能与感染耐药菌有关。此外，对氧氟沙星耐药者的疗效明显不及敏感者。结论目前氧氟沙星耐药率较低，故氧氟沙星不失为临床上一个新的、有效的抗结核药。
Objective To investigate the drug resistance of ofloxacin in hospitalized patients with pulmonary tuberculosis. Methods A retrospective investigation was conducted on the drug resistance of ofloxacin in 205 patients with positive TB sputum from patients with tuberculosis in our hospital from January 1993 to December 1995. Results 11 cases (17.5%) were secondary drug-resistant and 2 cases (1.4%) were primary drug-resistant. According to the analysis of the cases of ofloxacin-resistance, considering the long time of treatment and the equivalent of single drug Isofloxacin secondary to the causes of drug resistance; and the emergence of primary drug resistance, infection-resistant bacteria may be related. In addition, the efficacy of ofloxacin-resistant patients was significantly less sensitive than those who were sensitive. Conclusion Currently, ofloxacin has a low resistance rate, so ofloxacin may be a new and effective antituberculosis drug clinically.