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目的:研究广东地区乙型肝炎病毒基因型分布情况,B、C基因型与乙型肝炎患者临床表现之间的关系。方法:回顾性分析172例慢性乙型肝炎病毒患者[慢性乙型病毒性肝炎(CHB)、乙型肝炎后肝硬化(LC)、原发性肝癌(HCC)]的乙型肝炎病毒基因分型结果,并根据基因分型结果进行分组,比较B、C基因型患者的临床表现、HBe Ag定性、HBV-DNA定量、ALT及AST结果。结果:172例患者的乙肝病毒型分别为B型94例(54.7%)、C型69例(40.1%)、D型3例(1.7%)、未分型6例(3.5%);C型在LC组、HCC组中的比例与CHB组比较,差异有统计学意义(P<0.05);C型的HBe Ag阳性率高于B型(P<0.05);B、C型两组的ALT、AST差异有显著统计学意义(P<0.01);两组基因型间HBV-DNA水平的差异无统计学意义(P>0.05)。结论:广东地区HBV感染以B、C基因型为主,以B型居高;C基因型肝功能损害更严重,发展为肝硬化、肝癌的可能性更大,感染不同HBV基因型与HBV-DNA水平无明显相关。
Objective: To study the distribution of hepatitis B virus genotypes in Guangdong and the relationship between genotypes B and C and the clinical manifestations of hepatitis B patients. Methods: A retrospective analysis of hepatitis B virus genotypes in 172 patients with chronic hepatitis B virus [chronic hepatitis B (CHB), post-hepatitis B cirrhosis (LC), primary liver cancer (HCC)] Results According to genotyping results, the clinical manifestations, HBe Ag qualitative, HBV DNA quantification, ALT and AST were compared among patients with genotypes B and C. Results: Among 172 patients, 94 (54.7%) were type B, 69 (40.1%) were type C, 3 (1.7%) were type D and 6 (3.5% The positive rates of HBe Ag in type C were higher than those in type B (P <0.05), while those in type B and C were significantly higher than those in CHB (P <0.01). There was no significant difference in HBV-DNA levels between the two genotypes (P> 0.05). Conclusion: In Guangdong, HBV genotypes are predominantly B and C genotypes, and genotype B is high. Type C genotypes have more severe liver dysfunction and are more likely to develop cirrhosis and hepatocellular carcinoma. HBV genotypes and HBV- No significant correlation between DNA levels.