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目的研究摄入含有植物甾醇酯的牛奶对血脂指标的影响。方法从社区招募血胆固醇异常患者,随机分入植物甾醇酯牛奶组(n=59)、普通牛奶组(n=58)和不饮奶组(n=62),为期2个月。基线时3组受试者均接受健康教育和高胆固醇血症防治宣教。植物甾醇酯牛奶组和普通牛奶组每天饮用500 g牛奶,其中植物甾醇酯牛奶组的植物甾醇摄入量为1.58 g/d;不饮奶组在整个实验期内不食用任何奶制品。了解受试者身体活动水平,并每月随访一次血脂指标。结果共157人完成实验。干预1个月时,植物甾醇酯牛奶组的总胆固醇(TC)和低密度脂蛋白胆固醇(LDL-C)水平显著低于普通牛奶组,经校正后植物甾醇酯牛奶组与基线时相比TC差异无统计学意义,甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)水平显著升高,LDL-C水平显著降低,与普通牛奶组和不饮奶组相比时,各项血脂指标均无差异。干预2个月时,植物甾醇酯牛奶组的TC和LDL-C水平显著低于普通牛奶组和不饮奶组,经校正后植物甾醇酯牛奶组与基线时相比TC和LDL-C水平显著降低,TG水平显著升高,HDL-C水平无明显变化,与普通牛奶组和不饮奶组相比时,TC和LDL-C水平明显降低,TG和HDL-C在各组间差异无显著性。结论植物甾醇酯牛奶可显著降低血胆固醇异常患者的TC和LDL-C水平。
Objective To study the effects of intake of phytosterol-containing milk on blood lipids. Methods Patients with abnormal blood cholesterol levels were enrolled from the community and randomly assigned to phytosteryl ester milk (n = 59), normal milk group (n = 58), and non-milk group (n = 62) for 2 months. At baseline, all three groups received health education and prevention and treatment of hypercholesterolemia. Phytosterol ester milk group and normal milk group consumed 500 g milk a day, of which phytosterol ester milk group had a phytosterol intake of 1.58 g / d. The non-dairy milk group did not consume any dairy products throughout the experimental period. Understand the subject’s level of physical activity, and follow-up once a month lipid indicators. A total of 157 people completed the experiment. The level of total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) in phytosterol-ester milk group was significantly lower than that in normal milk group at 1 month after intervention, and the corrected phytosterol ester milk group was significantly lower than TC The difference was not statistically significant, triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) levels were significantly increased, LDL-C levels were significantly lower, compared with the normal milk group and no milk group, the No differences in blood lipid indicators. TC and LDL-C levels in phytosterol ester milk group were significantly lower than those in normal milk group and non-milk group after intervention for 2 months. TC and LDL-C levels were significantly higher in phytosteryl ester milk group than baseline TG and HDL-C levels did not change significantly, TC and LDL-C levels decreased significantly compared with the normal milk group and non-milk group, TG and HDL-C in each group had no significant difference Sex. Conclusions Phytosterol ester milk can significantly reduce TC and LDL-C levels in patients with abnormal blood cholesterol.