遗传性椭圆形红细胞增多症(HE)是一类异质性的综合征,在不同病例间的临床表现、红细胞形态和分子病理学都各不相同。HE的患病率约250—500/百万人。临床表现各病例间差异较大,从完全无症状到伴有椭圆形红细胞、小球形红细胞和异形红细胞的严重溶血性贫血。有症状者只占全部病例的10 Hereditary oval polycythemia (HE) is a heterogeneous syndrome, clinical manifestations in different cases, red blood cell morphology and molecular pathology are different. The prevalence of HE is about 250-500 per million people. Clinical manifestations vary greatly from case to case and range from asymptomatic to severe hemolytic anemia associated with oval red blood cells, small spherical red blood cells, and irregular red blood cells. Symptoms accounted for only 10% of all cases