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目的探讨妊娠期肥胖和子痫前期与孕产妇及新生儿维生素D水平缺乏之间的关系。方法将2011年6月-2015年3月间纳入标准的胎龄≥34周临产孕妇105例,分为子痫前期/非肥胖、子痫前期/肥胖、非子痫前期/肥胖、非子痫前期/非肥胖4组。采集母亲外周血和新生儿脐带血,采用化学发光法检测25-OH-维生素D水平。结果子痫前期较非子痫前期孕妇产下的新生儿25-OH-维生素D水平中位数更低(子痫前期/非肥胖组34.5%,子痫前期/肥胖组30.8%;非子痫前期/非肥胖组53.6%,非子痫前期/肥胖组59.1%;P<0.01),而肥胖组孕产妇及其新生儿的25-OH-维生素D缺乏者较非肥胖组高,差异无统计学意义(P>0.01)。新生儿25-OH-维生素D水平与母亲存在显著相关性(r=-0.067,P=0.01)。结论子痫前期孕妇及其新生儿更易出现25-OH-维生素D缺乏,肥胖对25-OH-维生素D无显著影响,同时,肥胖孕妇供给胎儿较少的25-OH-维生素D。
Objective To investigate the relationship between obesity in pregnancy and preeclampsia and the lack of vitamin D levels in pregnant women and newborns. Methods Between June 2011 and March 2015, 105 pregnant women of gestational age ≥34 weeks were enrolled in the study. They were divided into preeclampsia / non-obesity, preeclampsia / obesity, non-preeclampsia / obesity, non-preeclampsia Pre / non-obese 4 groups. Mother’s blood and neonatal cord blood were collected and the level of 25-OH-vitamin D was detected by chemiluminescence. Results The median neonatal 25-OH-vitamin D was lower in preeclampsia than non-preeclamptic pregnant women (34.5% in preeclampsia / non-obese group and 30.8% in preeclampsia / obesity group; non-preeclampsia Pre-term / non-obese group 53.6%, non-pre-eclampsia / obesity group 59.1%; P <0.01), while the obese group of pregnant women and their newborns 25-OH- vitamin D deficiency than non-obese group, Significance (P> 0.01). Neonatal 25-OH-vitamin D levels were significantly associated with maternal (r = -0.067, P = 0.01). Conclusion 25-OH-vitamin D deficiency is more likely to occur in pregnant women and their newborns with preeclampsia. Obesity has no significant effect on 25-OH-vitamin D, while obese pregnant women supply 25-OH-vitamin D with fewer fetuses.