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目的观察重组白细胞介素-2(IL-2)在难治性气胸中的治疗效果。方法将57例难治性气胸患者随机分为治疗组(IL-2组)和对照组(常规治疗组)。在胸腔闭式引流基础上,治疗组往胸腔内注入IL-2150万IU;而对照组只使用常规治疗方法。结果治疗组中获得满意疗效的例数明显高于对照组(P<0.001),而且治疗组中复发的例数明显低于对照组(P<0.01)。结论胸腔内注射白细胞介素-2治疗难治性气胸是一种简单、有效的方法。
Objective To observe the therapeutic effect of recombinant interleukin-2 (IL-2) in refractory pneumothorax. Methods 57 patients with refractory pneumothorax were randomly divided into treatment group (IL-2 group) and control group (conventional treatment group). On the basis of closed thoracic drainage, the treatment group injected IL-21.5 million IU into the thoracic cavity, while the control group only used conventional treatment. Results The number of patients with satisfactory curative effect in the treatment group was significantly higher than that in the control group (P <0.001), and the number of cases relapsed in the treatment group was significantly lower than that in the control group (P <0.01). Conclusions Thoracic injection of interleukin-2 in the treatment of refractory pneumothorax is a simple and effective method.