论文部分内容阅读
对 2 8例蛛网膜下腔出血 (SAH)后患者的血浆组织型纤溶酶原激活物 (t- PA)、纤溶酶原激活物抑制物 (PAI- 1)变化进行了观察 ,并与 30例健康者进行对照。结果显示 ,与对照组比较 ,SAH后 1～ 14天患者血浆纤溶活性明显增高 ;其中伴发脑血管痉挛 (CVS)者出血第 7天、 14天血浆 PAI- 1活性均明显高于无 CVS者 ;出血量多者血浆 t- PA、PAI- 1活性较高。提示血浆 t- PA、PAI- 1活性在 SAH后呈动态变化 ,二者可能均参与 SAH的发生、发展 ,其活性测定可望成为监测 SAH、 CVS及出血量的有效指标。
The changes of plasma tissue plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI-1) in 28 patients with subarachnoid hemorrhage (SAH) were observed and compared with 30 healthy controls. The results showed that compared with the control group, the plasma fibrinolytic activity of patients with SAH was significantly increased from 1 to 14 days after SAH. The plasma PAI-1 activity of the 7th day and the 14th day after hemorrhage with cerebral vasospasm (CVS) were significantly higher than those without CVS ; Those who have more bleeding plasma t-PA, PAI-1 activity higher. It is suggested that the plasma t-PA and PAI-1 activity changes dynamically after SAH, both of which may be involved in the occurrence and development of SAH. The determination of their activity is expected to be an effective indicator for monitoring SAH, CVS and blood loss.