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目的探讨阿托品联合奥美拉唑治疗急性胃炎患者的疗效及对炎性因子的影响。方法选取2015年4月至2016年7月于新疆哈巴河县人民医院接受诊治的100例急性胃炎患者作为研究对象,采用随机数字表法将其分为对照组和观察组,各50例。对照组患者采用山莨菪碱联合奥美拉唑治疗,观察组患者采用阿托品联合奥美拉唑治疗,比较两组患者症状改善时间、住院时间、治疗前后炎性因子水平及不良反应发生情况。结果观察组患者恶心呕吐、上腹部疼痛、腹泻消失时间及住院时间均明显短于对照组,差异均有统计学意义(均P<0.05);治疗后,观察组患者干扰素-β(IFN-β)、肿瘤坏死因子α(TNF-α)及白细胞介素-6(IL-6)水平均明显低于对照组,差异均有统计学意义(均P<0.05);观察组患者不良反应发生率明显低于对照组,差异有统计学意义(P<0.05)。结论阿托品联合奥美拉唑用于治疗急性胃炎,能有效降低炎性因子水平,促进患者早期恢复,且安全性较高。
Objective To investigate the curative effect of atropine and omeprazole in patients with acute gastritis and its influence on inflammatory factors. Methods A total of 100 cases of acute gastritis undergoing diagnosis and treatment in Hab River County People’s Hospital of Xinjiang from April 2015 to July 2016 were selected as study subjects and divided into control group and observation group by random number table. The patients in the control group were treated with anisodamine and omeprazole. The patients in the observation group were treated with atropine and omeprazole. The symptom improvement time, length of hospital stay, levels of inflammatory cytokines and the incidence of adverse reactions were compared between the two groups. Results The observation group patients with nausea and vomiting, upper abdominal pain, diarrhea disappear time and hospitalization time were significantly shorter than the control group, the difference was statistically significant (all P <0.05); after treatment, the observation group patients with interferon- β, TNF-α and IL-6 in the observation group were significantly lower than those in the control group (all P <0.05). Adverse reactions occurred in the observation group The rate was significantly lower than the control group, the difference was statistically significant (P <0.05). Conclusion Atropine combined with omeprazole for the treatment of acute gastritis, can effectively reduce the level of inflammatory cytokines, and promote early recovery of patients with high safety.