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为了探讨解毒通络方防治大鼠脑缺血再灌后DND的机理 ,采用大鼠双侧颈总动脉结扎合用腹腔注射硝普钠为模型 ,实验分为正常、模型、解毒通络方、尼莫地平 4组 ,用光化学方法检测造模后脑组织超氧化物歧化酶 (SOD)活性、丙二醛 (MDA)含量。发现模型组较正常组大鼠脑组织SOD降低 ,MDA升高 ,用解毒通络方、尼莫地平后可以明显提高SOD活性 ,降低MDA含量 ,前者较后者效果更明显。说明解毒通络方与尼莫地平均具有抗脂质过氧化损伤的能力 ,解毒通络方的作用更显著
To investigate the mechanism of Jie Du Tong Luo Fang in prevention and treatment of DND after cerebral ischemia and reperfusion in rats, the rats were subjected to bilateral common carotid artery ligation and intraperitoneal injection of sodium nitroprusside as a model. The experiment was divided into normal, model, Jiedu Tongluo, and Nepalese. In Modipine group 4, the activity of superoxide dismutase (SOD) and content of malondialdehyde (MDA) in the brain tissue were determined by photochemical method. It was found that SOD in the brain tissue of the model group was lower than that in the normal group, and MDA was increased. After using Jiedu Tongluo and Nimodipine, the activity of SOD and the content of MDA were significantly increased, and the former was more effective than the latter. It shows that Jiedu Tongluo and Nimodi have the ability to resist lipid peroxidation on average, and Jiedu Tongluo has a more significant effect