一、内毒素抗体作用的提出 1896年Pfelffer等将处于恢复期的伤寒患者血清输至豚鼠体内,使鼠获得了良好地对致死性伤寒细菌的攻击。[1]1904年,一种耐热的致热物质被发现,当时认为其是在细菌死亡溶溃后释放出的,故名内毒素。通过反复研究证明该物质 First, the proposed role of endotoxin antibody In 1896 Pfelffer other will be in the convalescence of typhoid patients serum lost to guinea pigs, the mice get a good attack on lethal typhoid bacteria. [1] In 1904, a thermostable pyrogenic substance was discovered, at the time it was thought to have been released after the bacterial death collapsed, hence the name endotoxin. The substance is proven by repeated studies