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近来已证实,HCV高变区1(HVR1)的单克隆抗体在体外能灭活相应的HCV。作者对一组HCV污染的抗-D免疫球蛋白(HCV-AD78)相同病毒株感染的患者,作感染期间HVR1抗体应答情况调查,并对急性自限性感染患者和慢性感染患者HVR1抗体出现时间进行比较。
It has recently been demonstrated that a monoclonal antibody to HCV hypervariable region 1 (HVR1) in vitro can inactivate the corresponding HCV. The authors investigated the response of an HVR1 antibody during infection to a group of patients infected with the same strain of HCV-infected anti-D immunoglobulin (HCV-AD78) as well as the onset of HVR1 antibody in patients with acute self-limiting infections and chronic infections Compare.