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目的:研究大黄廑虫丸预防和治疗肝纤维化的作用。方法:运用牛血清白蛋白致大鼠免疫损伤性肝纤维化模型,观察大廑黄虫丸对肝组织病理学、肝组织羟脯氨酸(HyP)和血清透明质酸(HA)及肝功能的影响,并设秋水仙碱作对照。结果:大黄廑虫丸预防和治疗组肝纤维化率分别为72.7％和71.4％,而模型组和秋水仙碱组肝纤维化率为92.3％～100％,尤其是大黄廑虫丸治疗试验组肝HyP含量下降最显著,与模型组比较,P<0.05。结论:大黄廑虫丸有一定的抗肝纤维化作用,尤适用于对肝纤维组织的降解。
Objective: To study the effect of rhubarb locust pills on preventing and treating liver fibrosis. METHODS: Bovine serum albumin was used to induce immune-induced liver fibrosis in rats. The pathological changes of liver tissue, liver tissue hydroxyproline (HyP), serum hyaluronic acid (HA) and liver function were observed. The effect of colchicine as a control. RESULTS: The liver fibrosis rate in the prevention and treatment group of Dahuangqichong Pills was 72.7% and 71.4%, respectively, while the liver fibrosis rate in the model group and colchicine group was 92.3% to 100%, especially in the treatment group of Dahuangqichong Pills. The level of liver HyP decreased most significantly, compared with the model group, P<0.05. Conclusion: Rhubarb has a certain anti-hepatic fibrosis effect, especially suitable for the degradation of liver fibrous tissue.