三唑仑(三唑安定,triazolam)系苯二氮草类催眠镇静药,其紫外吸收λ_(max)为222nm。因为本品片剂的溶出液最大可能浓度为0.5 μg/ml,如直接测定灵敏度不够。USPXXI版规定用HPLC法测定。为使测定方法简便、价廉,我们选用液固萃取法富集片剂的溶出液,再用光度法测定。应用化学键合相硅胶和大孔吸附树脂进行液固萃取已有文献报道。对于固定相的净化,文献中引用的方法也很多,然而多数是富集后进行色谱测定,如在紫外短波长区测定,这就要求过吸附剂的空白淋洗液在样品测定波长处 Triazolam is a benzodiazepine hypnotic sedative drug with a UV absorbance λ max of 222 nm. Because the tablets of the maximum possible concentration of the eluate 0.5μg / ml, such as the direct determination of sensitivity is not enough. USPXXI version of the determination by HPLC method. In order to make the determination method simple and inexpensive, we choose the liquid-solid extraction method to enrich the dissolution solution of the tablet and measure it by photometry. The use of chemical bonded silica and macroporous resin for liquid-solid extraction has been reported in the literature. There are many methods cited in the literature for the purification of stationary phases, however, most of them are chromatographed after enrichment, as measured in the UV-short wavelength region, which requires that the blank eluent of the over-adsorbent be detected at the sample measurement wavelength