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洛哌胺(loperamide)、吗啡sc抑制小鼠胃肠推进运动的ID_(50)分别为0.957、10.4 mg/kg。洛哌胺sc<80mg/kg并不引起小鼠产生吗啡样行为反应,而吗啡sc引起吗啡样反应的ED_(50)为9.42 mg/kg。洛哌胺和吗啡
The loperamide and morphine sc inhibited the gastrointestinal motility of mice with ID_ (50) of 0.957,10.4 mg / kg, respectively. Loperamide sc <80 mg / kg did not cause morphine-like behavioral response in mice, whereas morphine sc caused morphine-like ED_ (50) of 9.42 mg / kg. Loperamide and morphine