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目的 :对比观察两种放疗方式治疗鼻咽癌的局控率及急性反应。方法 :6 0例N0 -2 患者随机分为两组 ,30例采用标准超分割 (HFR)方式放疗 ,总量DT 76 .8Gy;30例采用前后加速超分割 (AHFR)方式放疗 ,总量DT 72Gy。结果 :(1)两组的 2年总生存率为 88 33%。 2年无病生存率HFR和AHFR组分别为 86 6 7%和 83 33%。两组的局部控制率分别为 :HFR 96 6 7% ;AHFR93 33%。 (2 )AHFR组与HFR组的急性粘膜反应程度相似 ,AHRF组约低于HFR组 ,无显著性差异。 (3)放疗结束时局部肿瘤的近期消退率AHFR组低于HFR组 ,无显著性差异。半年时两者CT示消退率相同。结论 :AHFR组急性粘膜反应与HFR组相似 ,局控率和生存率有待进一步观察
Objective: To compare the two radiotherapy methods for the treatment of nasopharyngeal carcinoma of the control rate and acute response. Methods: Totally 60 patients with N0 -2 were randomly divided into two groups. 30 patients were treated with standard HFR radiotherapy and the total volume was 76.7 Gy. Thirty patients were treated with AHFR radiotherapy and the total dose of DT 72Gy. Results: (1) The 2-year overall survival rate was 88.33% in both groups. The 2-year disease-free survival rate was 86.67% and 83.33% in the HFR and AHFR groups, respectively. The two groups of local control rates were: HFR 96 6 7%; AHFR93 33%. (2) The degree of acute mucosal reaction in AHFR group and HFR group was similar, while that in AHRF group was lower than that in HFR group, with no significant difference. (3) The local regression rate of local tumor at the end of radiotherapy was lower in AHFR group than in HFR group, with no significant difference. Six months CT showed the same regression rate. Conclusions: The acute mucosal reaction in AHFR group is similar to HFR group, and the rate of control and survival rate need further observation