临床资料 4例均为男性。发病年龄29—62岁。病程8月—1年半。首发症状:2例为双下肢凹陷性水肿,2例为双下肢麻木,无力。4例均有足下垂及下肢肌萎缩,2例伴有手部肌萎缩;四肢腱反射减弱或消失。套式感觉障碍中2例为痛觉减退,2例为痛觉过敏;4例均有皮肤变黑,以颜面及肢体远端明显;均有乳房发育,乳晕加深以及多汗,性功能障碍,2例伴有杵状指,2例有少量心包积 4 cases of clinical data were men. Age of onset 29-62 years old. Course of August - a year and a half. The first symptom: 2 cases of depression of the lower extremity edema, 2 cases of numbness of both lower extremities, weakness. All the 4 cases had foot drooping and lower extremity muscle atrophy, and 2 cases had hand muscle atrophy. The tendon reflex decreased or disappeared. 2 cases had necking pain and 2 cases had hyperalgesia; 4 cases had darkening of the skin with obvious facial and distal limbs; 2 cases had breast development, areola, deepening, hyperhidrosis and sexual dysfunction Accompanied by clubbing, 2 cases had a small amount of pericardium