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目的 了解原发性干燥综合征 (pSS)的肺部损害。方法 选择 4 3例病人和 2 0例正常者或骨关节炎患者 ,进行了临床、放射学及肺功能的观察。结果 3 8例 ( 88 4 % ) pSS患者肺受累 ,其中 15例 ( 3 4 9% )为小气道损害 ,2 3例 pSS患者残气量 /总气量≥ 8,为高肺含气量 ,其 2 5 %肺活量最大呼气流量 (V ·0 2 5) ,5 0 %肺活量最大呼气流量 (V ·0 50 )较非高含气量组明显降低 (P <0 0 5 ) ,其呼吸困难也较明显 (P <0 0 5 )。 19例胸片及 1例高分辨率CT示肺间质损害 ,与肺功能及临床症状无平行关系。结论 pSS的系统损害中 ,肺脏特别是小气道是常见的靶器官 ,肺高含气量与小气道功能下降有关。
Objective To understand the lung damage of primary Sjogren’s syndrome (pSS). Methods 43 cases of patients and 20 normal subjects or patients with osteoarthritis were selected for clinical, radiological and pulmonary function observation. Results Thirty-eight (88.4%) patients with pSS had lung involvement, 15 (34.9%) with small airway damage, 23 with residual volume / total gas volume of 8 and high lung volume with 23 The maximum expiratory volume of vital capacity (V · 0 2 5) and the maximum expiratory volume of 50% (V · 0 50) were significantly lower than those of non-high content of air (P 0 05) (P <0 05). 19 cases of chest radiography and 1 case of high resolution CT showed interstitial lung injury, and lung function and clinical symptoms were not paralleled. Conclusions In the systemic damage of pSS, the lungs, especially the small airways, are common target organs. The high air content in the lungs is associated with decreased airway function.