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目的 寻找狼疮肾炎中细胞凋亡异常的新证据 ,探讨其在狼疮肾炎发病机制中的作用及其临床意义。方法 用电镜和TUNEL原位末端标记法对 14例狼疮肾炎、3 2例原发性肾小球肾炎和 5例正常肾组织细胞进行细胞凋亡检测。结果 狼疮肾炎组织细胞平均凋亡积分较原发性肾小球肾炎及正常肾组织明显增高 ,并发现有巨噬细胞吞噬凋亡细胞和凋亡小体现象。结论 细胞凋亡异常在狼疮肾炎的发生、发展中起一定作用。
Objective To search for new evidence of abnormal apoptosis in lupus nephritis and explore its role in the pathogenesis of lupus nephritis and its clinical significance. Methods The apoptosis of 14 cases of lupus nephritis, 32 cases of primary glomerulonephritis and 5 cases of normal renal tissue were examined by electron microscopy and TUNEL in situ. Results The average apoptotic score of lupus nephritis cells was significantly higher than that of primary glomerulonephritis and normal renal tissues, and macrophage phagocytosis of apoptotic cells and apoptotic bodies was found. Conclusion Abnormal apoptosis may play a role in the occurrence and development of lupus nephritis.