论文部分内容阅读
目的研究多杂环化合物的合成方法和抗菌活性。方法将 2 芳基 5 氯甲基 1,3,4 二唑(1a～ 1n)与哌嗪缩合得相应的双取代哌嗪目标化合物 (2a～ 2n)。用试管稀释法 ,研究目标化合物的体外抑菌活性。结果合成了 14个新化合物 ,其结构经MS、IR、1H NMR和元素分析确证。多数化合物在体外表现出较好的抑菌活性。结论双二唑杂环取代的哌嗪化合物有可能成为新型结构的抗菌药物。
Aim To study the synthetic methods and antibacterial activity of polyheterocyclic compounds. Method The 2-aryl 5-chloromethyl 1,3,4-oxadiazole (1a ~ 1n) was condensed with piperazine to give the corresponding bis-substituted piperazine target compounds (2a ~ 2n). The in vitro antibacterial activity of the target compounds was investigated by tube dilution method. Results 14 novel compounds were synthesized and their structures were confirmed by MS, IR, 1H NMR and elemental analysis. Most compounds showed good antibacterial activity in vitro. Conclusion The bis-oxadiazole heterocyclic substituted piperazine compound may become a new type of antibacterial drug.