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对第二线化疗无效、或第二线化疗后很快复发的何杰金氏病(HD)患者,预后很差。有报告说联用环己亚硝脲、鬼臼乙叉甙和波尼芥,获得治疗成功。泼尼芥是苯丁酸氮芥和强的松龙形成的一种酯,兼有烷化剂和类固醇的作用。作者改良此化疔方案,以环磷酰胺和强的松代替泼尼芥,四药皆用口服,治疗3例难治
Patients with Hodgkin’s disease (HD) who are refractory to second-line chemotherapy or relapse soon after second-line chemotherapy have a poor prognosis. It has been reported that in combination with cycloheximide, etoposide and phonazin, treatment was successful. Prednisolone is an ester formed by chlorambucil and prednisolone and acts as both an alkylating agent and a steroid. The authors modified this chemotherapy program, cyclophosphamide and prednisone instead of prednisone, four drugs are used orally, the treatment of three refractory