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苯海拉明是抗组织胺和轻度镇静的常用药物。对其毒性,很少有评价。文献报告该药,在抗组织胺治疗中,有20~50%病人有一些副作用,包括嗜睡.口于、尿频、眩晕、食欲不振、便秘和神经过敏。年幼儿童可有兴奋相的表现,伴有幻觉、运动失调、肌肉颤搐、发热、惊厥甚至心脏、呼吸衰竭死亡。作者报告1例因误服苯海拉明,几乎中毒致死,随后又发生少见的心律不齐。病例13个月,男孩,体重10公斤,误服苯海拉明100~150毫克,1小时内出现极度不安,送医院就诊,途中发生大发作性惊厥而呼吸停止,采用口对口呼吸抢救复苏。入院时仍有肌肉震颤、瞳孔散大、对光反应迟钝,眼大睁有恐惧表现。肛温38.6℃。给予苯巴
Diphenhydramine is a commonly used antihistamine and mild sedative drug. There is little evaluation of its toxicity. It has been reported in the literature that 20-50% of patients in antihistamines have some side effects, including lethargy, frequent urination, dizziness, loss of appetite, constipation and nervousness. Young children may have excited phase performance, accompanied by hallucinations, motor disorders, muscle twitching, fever, convulsions and even heart, respiratory failure death. The authors report that 1 patient died of almost poisoning due to diphenhydramine, followed by rare arrhythmia. Case 13 months, the boy, weighing 10 kg, 100 to 150 mg of diphenhydramine taken in an extremely uncomfortable within 1 hour, sent to the hospital for treatment, occurred on the onset of paroxysmal convulsions and respiratory arrest, the use of mouth-to-mouth resuscitation resuscitation. There was still muscle tremor on admission, mydriasis, unresponsive to light, eyes wide open fear behavior. Rectal temperature 38.6 ℃. Give phenobarb