论文部分内容阅读
疟疾的备用治疗(Stand-by therapy)是指在发热和流感样症状出现且无处及时求医时服用自备抗疟药。本文综述备用治疗这一概念的基本原则、可供选择的药物、影响治疗用药的因素以及在日益增长的对常规药物抗性情况下各种药物的效果和毒性。氯喹作为备用治疗药物的可能性很有限。甲氟喹(特别在泰国)是假定性治疗的主要药物,但偶有神经精神的副反应。最近研究又发现,迄今最为推崇的备用治疗药物——卤泛曲林能引起心电图QTc间期的延长。应急情况下的备用治疗亟待研究。
Stand-by treatment of malaria refers to taking self-prepared anti-malaria drugs when fever and flu-like symptoms appear and are nowhere to seek medical advice. This article summarizes the basic principles of the concept of standby therapy, the options available, the factors that influence the use of the medication, and the effects and toxicity of the various drugs under the growing prevalence of resistance to conventional drugs. Chloroquine is very limited as a potential remedy. Mefloquine (especially in Thailand) is a hypothetical drug of primary treatment, but occasionally neuropsychiatric side effects. Recent studies have also found that by far the most respected alternative therapies halibutramine can cause ECG QTc interval extension. Emergency treatment in urgent need of research.