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目的研究脑“免疫特免性”与癫痫发病的关系。方法用免疫细胞化学法观察IgG免疫反应阳性(IgG-IR)细胞在两种不同处理程序的正常成年、癫痫及尼莫地平作用下癫痫大鼠脑组织内分布情况。结果灌注大鼠,除癫痫组个别脑片散在弱IgG-IR细胞外,其余均阴性;未灌注大鼠,各组脑片均散布IgG-IR细胞;癫痫大鼠脑组织IgG-IR细胞分布较正常组增多(p<0.01);尼莫地平作用下癫痫大鼠脑组织内IgG-IR细胞分布与正常组比较无显著差异。结论脑“免疫特免性”在癫痫发病中具有一定意义。
Objective To study the relationship between brain immunity and epilepsy. Methods Immunocytochemistry was used to observe the distribution of IgG immunoreactive (IgG-IR) cells in the brain tissue of epileptic rats under normal adult conditions, epilepsy and nimodipine treated by two different treatments. Results In perfusion group, except for epilepsy group, individual brain slices were scattered in weak IgG-IR cells, while the others were negative. IgG-IR cells were distributed in each group of brain slices. The distribution of IgG-IR cells in brain tissue of epileptic rats The normal group increased (p <0.01). There was no significant difference in the distribution of IgG-IR cells in the epileptic rat brain tissue between nimodipine and normal group. Conclusion The brain “immunosuppressive” has some significance in the pathogenesis of epilepsy.