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目的:建立一个简单,创伤少大鼠癫痫模型,以期使该类型癫痫的研究更符合临床病理情况。方法:利用胸部挤压器造成暂时性缺血,复苏后声音诱发癫痫发作,记录其发作情况,分析脑电图变化,并作实验性治疗。结果:该模型成功率为43%,发作形式类似遗传性易感大鼠(GEPR),脑电图符合癫痫诊断,实验治疗效果明显。结论:全脑缺血诱发大鼠癫痫模型操作简便,制作成功率高,接近临床病理情况,值得在癫痫研究工作中推广使用
Objective: To establish a simple, less traumatic rat epilepsy model in order to make this type of epilepsy more in line with clinical and pathological conditions. Methods: Temporary ischemia was induced by chest compressors. After the resuscitation, the voice-induced seizures were recorded. The seizures were recorded. The changes of EEG were analyzed and the experimental treatment was performed. Results: The success rate of this model was 43%. The seizures were similar to those of genetically predisposed rats (GEPR). EEG was consistent with the diagnosis of epilepsy. The experimental results were obvious. Conclusion: The model of epilepsy induced by global cerebral ischemia in rats is easy to operate and has a high success rate of production and close to clinical and pathological conditions, so it is worth to promote the use of epilepsy in the research of epilepsy