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目的:探讨大剂量维生素D3对维生素D缺乏孕妇及新生儿的作用。方法:通过串联质谱法检测孕晚期孕妇(38孕周)检测血清25OHD2、25OHD3及其总量,筛选维生素D缺乏孕妇400例和新生儿400例,随机数字法分为对照组(n=400)和观察组(n=400)。对照组不补充维生素D3,观察组在孕妇在其38孕周时大剂量(4000IU/d)口服补充维生素D3一周,比较2组临床效果。结果:2组孕妇干预前25羟基维生素D水平比较差异无统计学意义(P>0.05);观察组孕妇干预后及新生儿(干预后)25羟基维生素D水平,高于对照组(P<0.05);相关性研究显示:孕妇干预前25羟基维生素D水平无相关性(P>0.05);孕妇及新生儿干预后25羟基维生素D水平呈正相关性(P<0.05)。结论:对于维生素D缺乏孕妇及新生儿在孕38周大剂量补充维生素D3效果理想,能改善孕妇及新生儿维生素D状况,值得推广应用。
Objective: To investigate the effect of high-dose vitamin D3 on vitamin D-deficient pregnant women and newborns. Methods: Serum 25OHD2,25OHD3 and its total quantity were detected by tandem mass spectrometry in pregnant women of the second trimester (38 weeks old). 400 pregnant women with vitamin D deficiency and 400 newborns were screened by random number method and divided into control group (n = 400) And observation group (n = 400). The control group was not supplemented with vitamin D3, the observation group in the 38 weeks of pregnancy when pregnant women large doses (4000IU / d) of oral vitamin D3 for one week, the clinical effects of two groups were compared. Results: There was no significant difference in serum 25-hydroxyvitamin D levels between the two groups before and after intervention (P> 0.05). The level of 25-hydroxyvitamin D was significantly higher in the observation group than in the control group after intervention (P <0.05) ); Correlation study showed that: pregnant women before the intervention of 25 hydroxyl vitamin D levels had no correlation (P> 0.05); pregnant women and newborns after the intervention of 25 hydroxy vitamin D levels were positively correlated (P <0.05). Conclusion: Vitamin D deficiency in pregnant women and newborns at 38 weeks of pregnancy large doses of vitamin D3 is ideal, can improve the status of vitamin D in pregnant women and newborns, it is worth to promote the application.