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目的 :探讨PCT在新生儿生后72小时内对于细菌感染性疾病的诊断价值。方法 :将120例生后72小时内住院的新生儿根据感染严重程度评分(SSS),分为重症感染、轻症感染和非感染对照组,进行PCT检测,并与IL-6,白细胞计数,中性粒细胞比例等炎性指标进行比较。结果:PCT在重症感染、轻症感染和非感染组的均数分别为:10.9±10.43ng/ml,2.21±1.81ng/ml,0.267±0.25ng/ml,三组间比较有显著性差异(P<0.05)。IL-6与PCT比较,两者在诊断新生儿细菌感染性疾病敏感性方面无显著性差异(P>0.05),IL-6在重症感染与轻症感染组之间的均数比较无显著性差异(P>0.05)。与PCT比较,白细胞计数、中性粒细胞比例在诊断新生儿细菌感染性疾病的敏感性低(P<0.05),且白细胞计数、中性粒细胞比例在三组之间的均数比较无显著性差异(P>0.05)。结论 :PCT可作为72小时内新生儿感染性疾病筛查的一个早期敏感性指标,可以较好预测感染的严重程度。
Objective: To investigate the diagnostic value of PCT for bacterial infectious diseases within 72 hours after birth. Methods: 120 newborns hospitalized within 72 hours after birth were divided into severe infection, mild infection and non-infection control group according to the severity of infection score (SSS). The PCT test was performed and compared with IL-6, leukocyte count, Neutrophil ratio and other inflammatory indicators were compared. Results: The mean of PCT was 10.9 ± 10.43ng / ml, 2.21 ± 1.81ng / ml and 0.267 ± 0.25ng / ml respectively in severe infection, mild infection and non-infection group, there were significant differences among the three groups P <0.05). Compared with PCT, there was no significant difference between IL-6 and PCT in the diagnosis of neonatal bacterial infectious disease (P> 0.05), and there was no significant difference between IL-6 and severe infection Difference (P> 0.05). Compared with PCT, the sensitivity of leukocyte count and neutrophil ratio in the diagnosis of neonatal bacterial infectious disease was low (P <0.05), and the mean of white blood cell count and neutrophil ratio among the three groups was insignificant Sex differences (P> 0.05). Conclusion: PCT can be used as an early screening index for neonatal infectious disease screening within 72 hours, which can better predict the severity of infection.