论文部分内容阅读
应用体外培养和体内抑瘤实验以及细胞化学方法研究了新型光敏剂类卟啉化合物ＴＰ－１、ＴＰ－２对癌细胞的光敏效应，观察了该配合物对癌细胞的抑制、杀伤作用以及比较其在几种组织中的余留含量。结果表明，ＴＰ－１、ＴＰ－２均能明显地抑制体外人胃腺癌ＭＧＣ－８０３细胞，与对照组比较Ｐ＜０．０１，对Ｃ５７ＢＬ／６Ｊ、昆明小鼠体内腹水癌Ｓ１８０细胞杀伤作用均明显增强，腹水生成减少，细胞死亡百分率增加，与对照组比较Ｐ＜０．０１，结果提示ＴＰ－１、ＴＰ－２对癌细胞有较大亲和力，达到较好的光敏效应和抑瘤效果
The photosensitizing effects of the novel photosensitizer porphyrin compounds TP-1 and TP-2 on cancer cells were studied by in vitro culture, tumor inhibition experiments in vivo and cytochemical methods. The inhibition and killing effects of the complexes on cancer cells were observed and compared. Its remaining content in several tissues. The results showed that TP-1 and TP-2 all significantly inhibited human gastric adenocarcinoma MGC-803 cells in vitro, and compared with the control group, P<0.01. The killing effects of S180 cells on ascites carcinoma in C57BL/6J and Kunming mice were both significant. Significantly increased, decreased ascites production, increased percentage of cell death, compared with the control group P <0.01, the results suggest that TP-1, TP-2 has a greater affinity for cancer cells, to achieve better photosensitizing effect and anti-tumor effect