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采用原位杂交方法对 50例尖锐湿疣组织进行 HPV6B、11型检测。其中光镜诊断为尖锐湿疣的 2 3例中 14例阳性 ,阳性率 60 .9% ;光镜诊断符合尖锐湿疣的 2 7例中 7例阳性 ,阳性率 2 5.9%。结果提示 :原位杂交方法对尖锐湿疣的诊断、鉴别诊断、防止误诊、漏诊 ,提高确诊率 ,可以提供直接可靠的依据。图像定量分析对于判断 HPV感染的程度及其 DNA含量有一定意义。
Fifty cases of condyloma acuminatum tissues were tested by HPV6B and 11 by in situ hybridization. Of the 23 cases diagnosed as condyloma acuminatum, 14 were positive and the positive rate was 60.9%. Seven of 27 cases diagnosed as condyloma acuminatum by light microscope were positive with a positive rate of 2 5.9%. The results suggest that the method of in situ hybridization can provide a direct and reliable basis for the diagnosis and differential diagnosis of condyloma acuminatum, preventing the misdiagnosis, misdiagnosis and improving the diagnosis rate. Quantitative image analysis for the determination of the extent of HPV infection and DNA content of some significance.