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目的研究中药清开灵注射液防治小鼠酒精中毒性肝损伤的作用．方法采用Ｗｉｓｔａｒ♂大白鼠４０只，随机分为正常喂养组１０只，单纯酒精损伤组（正常喂养外每日灌注白酒）１５只，清开灵注射组（除上述处理外，每日皮下注射清开灵１ｍＬ）１５只．连续观察１２ｗｋ后，将上述３组动物全部处死，对其肝脏做病理组织学检查，并测血中肝功及血脂．结果正常喂养组和清开灵注射组肝脏病理组织学、血清肝功及血脂检查近似，而单纯酒精损伤组病理学检查与血清肝功、血脂均有异常，其肝功与血脂与正常喂养组相比有明显差异（Ｐ＜００５及Ｐ＜００１）．结论清开灵有较好的防治酒精性肝损伤作用，值得临床推广应用．
3. Objective To study the effect of Chinese herbal medicine Qingkailing injection on prevention and treatment of alcoholic liver injury in mice. Methods Forty Wistar rats were randomly divided into 10 normal feeding groups, 15 alcohol-only groups (15 normal daily infusions), and Qingkailing injection group (in addition to the above treatments, daily subcutaneous injection Kailing 1mL) 15. After 12 weeks of continuous observation, all the above three groups of animals were sacrificed, their livers were subjected to histopathological examination, and liver function and blood lipids were measured. RESULTS: Liver histopathology, serum liver function and blood lipids were similar in the normal feeding group and the Qingkailing injection group. The pathological examinations of the alcohol-only group and the abnormalities of serum liver function and blood lipid were similar. The liver function and blood lipids were normal and the normal feeding group was used. There was a significant difference compared to (P<005 and P<001). Conclusion Qingkailing has better prevention and treatment of alcoholic liver injury and is worthy of clinical application.