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一般认为,冠状动脉血流减少是心绞痛、心肌梗死、室性心律失常和心脏性猝死的主要原因。发病机理有冠状动脉因粥样硬化性狭窄、痉挛、粥样硬化斑块破裂继之出血、血栓形成以及对拟交感神经刺激的敏感性增加等。在上述机理中,血小板的激活甚为重要。血小板在动脉血栓形成中的作用已证实。激活的血小板也能合成血栓素A_2(一种强有力的血小板凝聚剂与血管收缩剂)。大量实验证明,冠状动脉内血小板的凝聚能造成心脏缺血和坏死。血小板的凝聚作用及其生存时间被用作检测心血管疾病病人的血小板高激活状态。Green等最近报道一种新方法研究疑有缺血性心脏病的病人在运动耐受试验时血小板的激活作用,即测定血浆中血小板因子4(PF-4,血小板激活时分泌的一种血小板蛋白)。
Is generally believed that coronary blood flow reduction is the main reason for angina pectoris, myocardial infarction, ventricular arrhythmia and sudden cardiac death. The pathogenesis of coronary atherosclerosis due to atherosclerosis, cramps, atherosclerotic plaque rupture followed by hemorrhage, thrombosis and increased sympathetic nerve stimulation and so on. In the above mechanism, the activation of platelets is very important. The role of platelets in arterial thrombosis has been demonstrated. Activated platelets also synthesize thromboxane A2 (a potent platelet coagulant and vasoconstrictor). A large number of experiments show that the coagulation of platelet within the coronary artery can cause heart ischemia and necrosis. Platelet aggregation and its survival time are used to detect elevated platelet activation in patients with cardiovascular disease. Green et al. Recently reported a new method to study platelet activation in patients with suspected ischemic heart disease during exercise tolerance testing, ie, platelet factor 4 (PF-4), a platelet protein secreted during platelet activation ).