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目的观察丹红注射液联合奥扎格雷钠对老年性脑梗死合并高血压病的临床疗效。方法将160例脑梗死合并高血压病老年患者随机分为对照组和观察组各80例,对照组给予奥扎格雷钠160 mg,每天1次;观察组在对照组基础上给予丹红注射液20 m L,每天1次。2周为1个疗程。观察两组临床疗效,比较治疗前后临床神经功能缺损程度评分(NDS)、Barthel指数评定量表(BI)、血压以及不良反应。结果观察组总有效率为93.75%,对照组总有效率为75.00%,观察组总有效率显著高于对照组,差异有统计学意义(P<0.05)。治疗前,观察组NDS评分为(24.01±7.61)分,BI评分为(38.14±6.42)分,对照组NDS评分为(24.08±7.93)分,BI评分为(38.45±8.02)分,两组治疗前NDS及BI比较,差异无统计学意义;治疗后,观察组NDS评分为(13.81±3.91)分,BI评分为(59.11±7.12)分,对照组NDS评分为(15.50±4.32)分,BI评分为(50.92±6.48)分,两组治疗后NDS及BI均明显优于治疗前,差异有统计学意义(P<0.05)。且治疗后观察组NDS及BI均明显优于对照组,差异有统计学意义(P<0.05)。治疗前,观察组患者平均收缩压(SBP)为(165.0±6.8)mm Hg,平均舒张压(DBP)为(101.0±5.9)mm Hg,对照组患者SBP(167.0±7.6)mm Hg,DBP(102.0±6.6)mm Hg;治疗后,观察组患者SBP(138.0±7.6)mm Hg,DBP(78.0±6.7)mm Hg,对照组患者SBP(135.0±8.1)mm Hg,DBP(80.0±7.2)mm Hg,各组治疗前后SBP和DBP比较,差异均有统计学意义(P<0.05),但两组之间差异无统计学意义。两组患者不良反应比较差异无统计学意义。结论奥扎格雷钠联合丹红注射液对老年脑梗死合并高血压病临床疗效明显优于单用奥扎格雷钠,且无严重不良反应,值得临床推广应用。
Objective To observe the clinical effect of Danhong injection combined with ozagrel on senile cerebral infarction with hypertension. Methods A total of 160 elderly patients with cerebral infarction and hypertension were randomly divided into control group and observation group, 80 cases in each group. Ozagrel sodium 160 mg once daily was given in the control group. Danhong injection 20 m L, 1 day. 2 weeks for a course of treatment. The clinical efficacy of the two groups were observed. The scores of NDS, Barthel index, blood pressure and adverse reactions were compared before and after treatment. Results The total effective rate was 93.75% in the observation group and 75.00% in the control group. The total effective rate in the observation group was significantly higher than that in the control group (P <0.05). Before treatment, the NDS score was (24.01 ± 7.61) in the observation group and (38.14 ± 6.42) in the BI group, (24.08 ± 7.93) in the control group and (38.45 ± 8.02) in the BI group After treatment, the score of NDS in the observation group was (13.81 ± 3.91) points, the BI score was (59.11 ± 7.12) points, the score of NDS in the control group was (15.50 ± 4.32) points, the BI Score (50.92 ± 6.48) points, NDS and BI after treatment were significantly better than before treatment, the difference was statistically significant (P <0.05). After treatment, NDS and BI in the observation group were significantly better than those in the control group, the difference was statistically significant (P <0.05). Before treatment, the mean systolic blood pressure (SBP) and the mean diastolic blood pressure (DBP) in the observation group were (101.0 ± 5.9) mm Hg and (167.0 ± 7.6) mm Hg and DBP 102.0 ± 6.6) mm Hg. After treatment, SBP (138.0 ± 7.6) mm Hg and DBP (78.0 ± 6.7) mm Hg in the observation group were significantly lower than those in the control group (SBP: 135.0 ± 8.1 mm Hg, DBP: 80.0 ± 7.2 mm Hg, SBP and DBP before and after treatment in each group, the differences were statistically significant (P <0.05), but there was no significant difference between the two groups. Adverse reactions between the two groups showed no significant difference. Conclusions Ozagrel combined with Danhong injection is superior to ozagrel sodium alone in the treatment of senile cerebral infarction complicated with hypertension, and has no serious side effects. It is worthy of clinical application.