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目的观察脾氨肽口服冻干粉联合重组人干扰素α-2b凝胶及阿达帕林凝胶治疗泛发性扁平疣的临床疗效。方法 59例患者随机分为两组,观察组给予口服脾氨肽冻干粉联合外用0.1%阿达帕林凝胶及重组人干扰素α-2b凝胶,对照组单给予外用阿达帕林凝胶、重组人干扰素α-2b凝胶。比较两组患者的临床疗效。结果观察组有效率87.50%,对照组有效率51.85%,观察组有效率显著高于对照组,差异有统计学意义(P<0.05)。观察组复发率(3.13%)显著低于对照组(11.11%)(P<0.05)。结论口服脾氨肽冻干粉联合外用阿达帕林凝胶及重组人干扰素α-2b凝胶可明显提高临床疗效,不良反应少,复发率低,值得在泛发性扁平疣治疗中应用推广。
Objective To observe the clinical efficacy of oral administration of splenic peptidase combined with recombinant human interferon α-2b gel and adapalene gel in the treatment of generalized flat warts. Methods 59 patients were randomly divided into two groups. The observation group was given oral spleen ammonia peptide lyophilized powder combined topical 0.1% adapalene gel and recombinant human interferon α-2b gel, the control group was given topical adapalene gel , Recombinant human interferon alpha-2b gel. The clinical efficacy of the two groups was compared. Results The effective rate was 87.50% in observation group and 51.85% in control group, and the effective rate in observation group was significantly higher than that in control group (P <0.05). The recurrence rate in the observation group (3.13%) was significantly lower than that in the control group (11.11%) (P <0.05). Conclusion The oral spleen ammonia peptide lyophilized powder combined with topical adapalene gel and recombinant human interferon alpha-2b gel can significantly improve the clinical efficacy, fewer adverse reactions, the recurrence rate is low, it is worth in the treatment of generalized flat wart application promotion .