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胰腺脑病(Pancreatic encephalopathy,PE)是胰腺炎,尤其是重症急性胰腺炎(severe acute pancreatitis,SAP)的严重并发症,死亡率高达67%～100%.国内15所医院735例急性胰腺炎患者中,PE 的发生率为11.2%.大多数发生在起病后1 d～7d内,表现为定向力障碍,幻觉,意识模糊等神经精神症状.极少数病例发生于起病后1 mo 左右,称之为迟发性胰腺脑病(latepancreatic encephalopathy,LPE).我们回顾性分析15例 LPE 患者的临床经过,总结该疾病的临床特征及其处理,旨在提高临床对 LPE 的早期识别能力,改善其临床预后.
Pancreatic encephalopathy (PE) is a serious complication of pancreatitis, especially severe acute pancreatitis (SAP), with a mortality rate as high as 67% -100%. Among 735 acute pancreatitis patients in 15 hospitals in China, , And the incidence of PE was 11.2%, most of which occurred within 1 d ~ 7 d after onset, showing neuropsychiatric symptoms such as disorientation, hallucination, confusion, etc. A very small number of cases occurred in about 1 month after onset, Which is latepancreatic encephalopathy (LPE) .We retrospectively analyzed the clinical experience of 15 patients with LPE and summarized the clinical features and treatment of LPE, in order to improve the clinical ability of early recognition of LPE and improve its clinical Prognosis.