患者,女,32岁,拟“风湿性心脏病,二尖瓣狭窄、关闭不全,房颤,心功能Ⅲ级”于1988年10月17日在全麻体外循环下行“二尖瓣置换术”。术后应用青霉素钠盐(每日静脉滴注1280万单位)、先锋V、丁胺卡那,术后第4天在继续使用青霉素钠盐的情况下,停用先锋V,改用氧哌嗪青霉素钠,首次推注(剂量为2g+10％GS20ml,5min内推完)后,患者立即出现烦燥不安,呼吸急促, Patients, female, 32 years old, proposed “rheumatic heart disease, mitral stenosis, insufficiency, atrial fibrillation, cardiac function grade Ⅲ” on October 17, 1988 in general anesthesia cardiopulmonary bypass “mitral valve replacement” . Postoperative application of penicillin sodium (daily intravenous infusion of 12.8 million units), Vanguard V, amikacin, the first 4 days after the continued use of penicillin sodium case, disable Pioneer V, Penicillin sodium, the first bolus (dose of 2g + 10% GS20ml, 5min push End), the patient immediately irritable, shortness of breath,