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本文介绍对随访4年的28例系统性红斑狼疮(SLE)合并中枢神经系统损害应用激素治疗的估价。患者均为女性,有血清补体减少,抗DNA抗体增加及多系统损害。有8例出现10次癫痫发作,其中5例用强的松量≥200毫克/日者,3例死于合并感染,而用小剂量强的松者则恢复。器质性脑损害呈精神错乱、痴呆、有或无神经系统体征者共9例,应用强的松剂量≥200毫克/日的4例,1例遗痴呆,1例突然死于心肌病变,2例死于合并感染,另5例用强的松量30～120毫克/日者,2例呈慢性痴呆,3例完全恢复。无荫性脑膜炎共4例,用强的松100毫克/日者脑膜炎呈良性经过,随病人情况好转而改善,死后遗症。其它中
This article describes the evaluation of hormone therapy in 28 patients with systemic lupus erythematosus (SLE) complicated with central nervous system injury for a follow-up of 4 years. All patients were female with reduced serum complement, increased anti-DNA antibodies and multiple system damage. There were 8 epileptic seizures in 10 patients, of whom 5 had prednisone> 200 mg / day, 3 died of coinfection, and those with low-dose prednisone recovered. Organic brain damage was insanity, dementia, with or without signs of nervous system in 9 cases, the application of prednisone dose ≥ 200 mg / day in 4 cases, 1 case of dementia, 1 case of sudden death from myocardial lesions, 2 Cases died of co-infection, the other 5 cases with prednisone 30 ~ 120 mg / day, 2 were chronic dementia, 3 patients completely recovered. Shade-free meningitis in 4 cases, with prednisone 100 mg / day meningitis was benign, with the improvement of the patient’s condition and death sequelae. Other