气相色谱法作为一种高效、灵敏、快速和简便的分离技术已用于有机合成化学方面。近年来,色谱法已从原料、中间体和产物的分析鉴定发展到自反应体系中直接测定反应产率,为反应微量化、缩短实验周期以及简化实验操作提供了有利的条件。在研究用冠醚催化酸性磷(膦)酸酯的酯化反应中,我们用气液色谱法定量分析反应体系中原料的变化,效果良好。该反应系利用冠醚对阳离子的很强的络 Gas chromatography has been used in organic synthesis chemistry as an efficient, sensitive, rapid and simple separation technique. In recent years, the chromatographic method has been developed from the analysis and identification of raw materials, intermediates and products to directly determine the reaction yield in the self-reaction system, which provides favorable conditions for the reaction miniaturization, shortening the experimental period and simplifying the experimental operation. In the study of crown ether-catalyzed esterification of acidic phosphorus (phosphonates), we used gas-liquid chromatography to quantitatively analyze the changes of the raw materials in the reaction system. The reaction takes advantage of the strong cations of cations with crown ethers