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目的 探讨研究血降钙素原、乳酸对脓毒血症患者预后的临床意义.方法 2009年1月-2014年12月无锡第四人民医院收治的48例脓毒血症患者,按预后分为存活组和死亡组,比较两组患者发病早期血降钙素原、乳酸水平及急性生理与慢性健康状况(APACHE Ⅱ评分),并通过ROC曲线分析两种标记物对患者预后评估的临床价值.结果 通过两组间比较死亡组PCT和乳酸均大于存活组(P＜0.05),死亡组APACHEⅡ评分均大于存活组(P＜0.05);两种标记物与APACHEⅡ评分存在一定相关性,两种标记物阳性项目及APACHEⅡ评分越高,死亡率越高,呈正相关趋势;3种标记物预测死亡的ROC曲线下面积在0.7～0.81之间.结论 血降钙素原、乳酸水平高低对患者死亡率有较高的预测价值,联合检测可以提高敏感性及更准确评价脓毒症的预后.“,”Objective To investigate the clinical value of procalcitonin (PCT) and lactic acid in accessment of prognosis in patients with sepsis.Methods 48 patients with sepsis,including 38 suviving (survival group) for at least 28d and 10 who died within 28d after admission to the ICU (death group).Peripheral bloodsamples were collected within 24 h after hospitalization to test the levels of PCT and lactic acid,and APACHE Ⅱ rating was recorded,Pearson correlation analysiswas conducted.ROC curve was established to evaluate the predictive valuesof these markers in prognosis.Result The levles of PCT and lactic acid and the APACHE Ⅱ score of the survival group were all significantly lower than those of the death group (all P ＜0.05).The levles of PCT and lactic acid were both positive correlated the APACHE Ⅱ score (both P ＜0.05).The higher the evles of PCT and lactic acid and the APACHE Ⅱ score,the higher the mortality rate.Conclusion the levles of PCT and lactic acid have rather high precative values for the prognosis of the patients with sepsis.