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目的探讨社区老年原发性高血压合并糖尿病采取缬沙坦联合氨氯地平治疗的临床疗效。方法 92例老年原发性高血压合并糖尿病患者,按随机数字表法分为对照组和观察组,各46例。对照组给予缬沙坦治疗,观察组在对照组治疗基础上给予缬沙坦联合氨氯地平治疗,治疗2个月后,比较两组治疗效果及不良反应。结果观察组治疗后空腹血糖、血肌酐、血尿素氮、内生肌酐清除率均低于对照组,差异有统计学意义(P<0.05);观察组治疗总有效率为95.65%,高于对照组的78.26%,差异有统计学意义(P<0.05);两组不良反应比较,差异无统计学意义(P>0.05)。结论对老年原发性高血压合并糖尿病患者采取缬沙坦联合氨氯地平治疗的疗效较好,有效控制血糖、血压,且用药安全。
Objective To investigate the clinical efficacy of valsartan combined with amlodipine in the elderly with essential hypertension in the community. Methods Ninety-two elderly patients with essential hypertension complicated with diabetes mellitus were divided into control group and observation group according to random number table method, 46 cases each. The control group was treated with valsartan. The observation group was treated with valsartan and amlodipine on the basis of the control group. After 2 months of treatment, the therapeutic effect and adverse reactions of the two groups were compared. Results After treatment, the fasting blood glucose, serum creatinine, blood urea nitrogen and creatinine clearance in the observation group were lower than those in the control group (P <0.05). The total effective rate in the observation group was 95.65% The difference was statistically significant (P <0.05). There was no significant difference between the two groups in adverse reactions (P> 0.05). Conclusion The effect of valsartan combined with amlodipine on elderly patients with essential hypertension complicated with diabetes is better and the blood sugar and blood pressure are controlled effectively, and the medication is safe.