铂类系有效的广谱抗实体肿瘤(包括卵巢癌)药物,具有胃肠道、肾、神经及过敏性反应毒性。现报道1例卵巢癌患者因接受极小量顺铂后出现严重过敏反应而致死。 患者58岁,G_6P_4Ab_2,诊断为卵巢宫内膜样腺癌Ⅲ_c期,行彻底的肿瘤细胞减灭术后,环磷酰胺(1000mg/m~2)+顺铂(50mg/m~2)化疗12疗程,CA125水平正常,仅存在轻度骨髓抑制。二探术阴性,已无瘤生存4年。常规随访检查发现CA125为62, Platinum is an effective broad-spectrum anti-solid tumor (including ovarian cancer) drug with gastrointestinal, renal, neurological, and allergic toxicity. One case of ovarian cancer is reported to have died of severe allergic reactions after receiving a small amount of cisplatin. 58-year-old patient, G_6P_4Ab_2, diagnosed with ovarian endometrial adenocarcinoma III_c phase, after thorough cytoreductive surgery, cyclophosphamide (1000mg/m~2) + cisplatin (50mg/m~2) chemotherapy 12 During the course of treatment, CA125 levels were normal and only mild myelosuppression was present. The two probes were negative and had been tumor-free for 4 years. Routine follow-up examination found that CA125 was 62.