疟疾作为当前人类三大传染病之一,是人类疾病防治领域的一大难题和挑战,特别是疟原虫复杂的生活史和多变的病原相关基因表达调控方式使得对其的防治任务更加艰巨。这其中一个重要的制约因素是目前对调控疟原虫基因表达的表观遗传机制缺乏透彻的了解[1]。在可以感染人类的五类疟原虫当中,最严重的恶性疟原虫(Plasmodium falciparum) As one of the three major human infectious diseases, malaria is a major challenge and challenge in the field of human disease prevention. In particular, the complicated life history of malaria parasites and the changing ways of gene expression control of pathogens make the task of prevention and treatment more difficult. One of the most important constraints is the lack of a thorough understanding of the epigenetic mechanisms governing the gene expression of Plasmodium [1]. Among five types of Plasmodium that can infect humans, the most severe Plasmodium falciparum