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目的探讨胚胎发育不良性神经上皮肿瘤(DNT)的临床及病理特点。方法对近年来收治的5例DNT的临床症状和体征、影像学、电生理及病理学资料进行了回顾性分析。结果 DN T典型的临床表现为难治性癫痫,绝大多数于20岁以前发病,男性多于女性。病变多位于幕上,影像学检查与其他低级别胶质瘤难以鉴别。5例均于全麻下行开颅肿瘤全切除术,术后癫痫发作消失,病理均证实为DNT。随访3个月-5年,无肿瘤复发。结论 DNT是手术可治愈的良性病变,预后良好, 无需放疗和化疗。
Objective To investigate the clinical and pathological features of embryonic dysplastic neuroepithelial neoplasm (DNT). Methods The clinical symptoms and signs, imaging, electrophysiological and pathological data of 5 cases of DNT admitted in recent years were retrospectively analyzed. Results The typical clinical manifestations of DN T were refractory epilepsy, the vast majority of the onset of the age of 20, more men than women. More lesions on the screen, imaging and other low-grade glioma difficult to identify. 5 cases underwent craniotomy under general anesthesia tumor resection, epileptic seizures disappeared after the pathology confirmed as DNT. Follow-up 3 months - 5 years, no tumor recurrence. Conclusions DNT is a surgically treatable benign disease with a good prognosis without radiotherapy and chemotherapy.