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目的:探讨乙肝病毒(Hepatitis B virus,HBV)感染与B细胞型非霍奇金淋巴瘤(B-cell Non-Hodgkin’s Lymphoma,B-cell NHL)的相关性。方法:回顾性分析2008年1月至2014年1月我院232例NHL患者作为研究组,另选取经病理学、影像学等诊断为其他类型肿瘤的患者230例作为对照组。比较两组研究对象HAV、HBV及HCV的感染情况。结果:研究组患者HBs Ag阳性率高于对照组,差异具有统计学意义(P<0.05);但两组患者Anti-HAV和Anti-HCV阳性率无明显差异(P>0.05)。B-cell NHL患者HBs Ag阳性率高于对照组和T-cell NHL患者,差异具有统计学意义(P<0.05)。T-cell NHL患者HBs Ag阳性率与对照组无显著差异(P>0.05)。B-cell NHL年轻患者HBs Ag阳性率高于T-cell NHL患者,差异具有统计学意义(P<0.05)。B-cell NHL患者Anti-HBs、HBe Ag、Anti-HBe及Anti-HBc阳性率与对照组存在明显差异(P<0.05);而T-cell NHL患者与对照组无显著差异(P>0.05)。结论:B-cell NHL感染HBV的几率较高,HBV感染与B-cell NHL早期发病有明显的关联性。
Objective: To investigate the correlation between Hepatitis B virus (HBV) infection and B-cell non-Hodgkin’s Lymphoma (B-cell NHL). Methods: A retrospective analysis of 232 patients with NHL in our hospital from January 2008 to January 2014 was selected as the study group. Another 230 patients diagnosed as other types of tumors by pathology and imaging were selected as the control group. The infection status of HAV, HBV and HCV in two groups were compared. Results: The positive rate of HBsAg in the study group was higher than that in the control group (P <0.05). However, there was no significant difference in the positive rates of Anti-HAV and Anti-HCV between the two groups (P> 0.05). The positive rate of HBsAg in B-cell NHL patients was higher than that in control group and T-cell NHL patients (P <0.05). The positive rate of HBsAg in T-cell NHL patients was not significantly different from that of the control group (P> 0.05). The positive rate of HBsAg in young patients with B-cell NHL was higher than that in patients with T-cell NHL, the difference was statistically significant (P <0.05). The positive rates of Anti-HBs, HBeAg, Anti-HBe and Anti-HBc in B-cell NHL patients were significantly different from those in the control group (P <0.05) . Conclusion: The risk of HBV infection in B-cell NHL is high, and HBV infection is obviously associated with the early onset of B-cell NHL.