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毛细胞白血病(HCL)染色体异常甚少见,若存在亦是非克隆性的.迄今已报道了一些复杂克隆性染色体异常的病例.本文报道二例相同克隆的14号染色体重排.例1,男性患者45岁,脾肿大,WBC8.3×10~9/L,非典型异常细胞73%,这似乎居于毛细胞和幼淋巴细胞之间.按照Cawty等分类法诊断为变异型HCL.治疗前染色体研究,用PHA,美州商陆丝裂原(PWM)和L881(NOC)刺激培养的血细胞.以PHA和NOC刺激的淋巴细胞中期分裂相中,在前者14q-占2/58,后者占71/75,这
Chromosome abnormalities in hairy cell leukemia (HCL) are rare and, if present, are also non-clonal. Some cases of complex clonal chromosomal abnormalities have been reported. Two chromosomal rearrangements of the same clone were reported in this paper. 45 years of age, splenomegaly, WBC 8.3 × 10 ~ 9 / L, atypical abnormal cells 73%, which seems to be living in hair cells and lymphocytes in lymphocytes according to Cawty classification of variant HCL diagnosis before treatment Chromosomal studies showed that the cultured blood cells were stimulated with PHA, Meriones praecox (PWM) and L881 (NOC), whereas the former divided by 14q-2/58 in PHA and NOC-stimulated metaphase cells Accounting for 71/75, this