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现实情况表明,癌化学疗法的基础研究与临床,尚未达到人们的最终目的。其理由除药物选择性差以外,主要是: 1.在癌细胞中存在着抗癌药无效的细胞,所以抗癌药不能杀死所有的癌细胞; 2.在治疗过程中,抗癌药会逐渐失去疗效。当癌症复发时,往往会引起死亡。这两点是目前化疗所面临的大问题。本文将这两点称作耐药性。由宿主因素引起的耐药性,如抗癌药在体内的代谢、失活、排泄增加,因人而异,用目前的理论处理尚有困难。细胞水平的耐药性在临床上也具有重要
The reality shows that the basic research and clinical cancer chemotherapy has not yet reached the ultimate goal of people. The reason for the poor selectivity of drugs other than the main are: 1. There is cancer cells in the anti-cancer drugs ineffective cells, so anti-cancer drugs can not kill all the cancer cells; 2. In the course of treatment, anti-cancer drugs will gradually Loss of efficacy. When cancer recovers, it often causes death. These two points are the major problems facing the current chemotherapy. This article refers to these two as drug resistance. Drug resistance caused by host factors, such as the increase in in vivo metabolism, inactivation and excretion of anti-cancer drugs, varies from person to person, with current theoretical difficulties. Cell-level resistance is also clinically important