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A new impurity was detected during high performance liquid chromatographic(HPLC) analysis of eslicarbazepine acetate active pharmaceutical ingredient.The structure of unknown impurity was postulated based on liquid chromatography mass spectrometry using electrospray ionization and ion trap analyzer(LC/ESI-IT/MS) analysis.Proposed structure of impurity was unambiguously confirmed by synthesis followed by characterization using ~1H,~(13)C nuclear magnetic resonance spectrometry(NMR),~1H-~1H correlation spectroscopy(COSY) and infrared spectroscopy(IR).Based on the spectroscopic and spectrometric data,unknown impurity was characterized as 5-carbamoyl-10,11-dihydro-5H-dibenzo[b,f]azepin-10-yl propionate.
A new impurity was detected during high performance liquid chromatographic (HPLC) analysis of eslicarbazepine acetate active pharmaceutical ingredient. The structure of unknown impurity was postulated based on liquid chromatography mass spectrometry using electrospray ionization and ion trap analyzer (LC / ESI-IT / MS) analysis.Proposed structure of impurity was unambiguously confirmed by synthesis followed by characterization using ~ 1H, ~ (13) C nuclear magnetic resonance spectrometry (NMR), ~ 1H- ~ 1H correlation spectroscopy (COZY) and infrared spectroscopy (IR) the spectroscopic and spectrometric data, unknown impurity was characterized as 5-carbamoyl-10,11-dihydro-5H-dibenzo [b, f] azepin-10-yl propionate.