1992年2月11日自然杂志报道:美国加州Goeddel,D.V.等人首次成功地鉴定出人类免疫干扰素珈玛(IFN-γ)蛋白基因密码DNA序列。并且利用DNA重组技术获得了由大肠杆菌和培养中的猴细胞表达产生出与人类免疫干扰素珈玛蛋白具有同样特性的蛋白质。并确定在IFN-γ基因密码中含有一个内含子(Intron),而IFN-α和IFN-β都不含有内含子 February 11, 1992 In Nature: Goeddel, D.V. et al., California, USA, for the first time successfully identified the human immunodepressin gamma (gamma) protein gene coding DNA sequence. And the use of recombinant DNA technology to obtain a protein from Escherichia coli and cultured monkey cells to produce human immunodeficiency gamma protein has the same characteristics. And confirmed that there is an intron in the IFN-γ gene code (Intron), while neither IFN-α nor IFN-β contains introns