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目的 :研究雌二醇对大鼠心脏分泌利钠肽的影响 ,为临床应用提供理论依据。方法 :采用电镜观察右心耳肌细胞心房特殊颗粒 ,放射免疫分析法测定血浆利钠肽水平等研究方法 ,研究雌二醇对心脏分泌利钠肽的影响。结果 :卵巢切除组心房特殊颗粒、血浆利钠肽水平与伪手术组、卵巢切除E2 组相比明显减少 ,差异呈显著性 (P <0 .0 5 )。结论 :雌二醇对大鼠心脏利钠肽的合成和分泌有促进作用。
Objective: To study the effect of estradiol on the secretion of natriuretic peptide in rat heart and to provide a theoretical basis for clinical application. Methods: Electron microscopy was used to observe the atrial appendage of right atrial myocytes and radioimmunoassay to determine the level of plasma natriuretic peptide. The effects of estradiol on cardiac secretion of natriuretic peptide were studied. Results: The atrial natriuretic peptide and plasma natriuretic peptide levels in ovariectomized group were significantly decreased compared with sham operation group and ovariectomized E2 group (P <0.05). Conclusion: Estradiol can promote the synthesis and secretion of natriuretic peptide in rat heart.