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目的探讨化生性胸腺瘤的临床病理学和生物学行为特点。方法对2例纵隔化生性胸腺瘤进行临床特征、组织病理形态学、影像诊断学和免疫组化研究,并复习相关文献。结果 2例患者均为男性,分别为35、38岁,CT提示前纵隔占位,境界清楚。组织学表现为典型的双相性表现,上皮细胞区域和梭形细胞区域交错分布,间质散在少许淋巴细胞,肿瘤细胞无明显异型性。免疫表型:上皮细胞区域Ckpan(+),CD5(-),梭形细胞区域Vimentin(+),Ckpan(-)。结论化生性胸腺瘤是一种少见的肿瘤,有着与普通胸腺瘤截然不同的组织学形态,肿瘤一般无复发或转移,是一种恶性潜能较低的胸腺瘤亚型。
Objective To investigate the clinicopathological and biological behavior of metaplastic thymoma. Methods The clinical features, histopathology, imaging diagnosis and immunohistochemistry of 2 cases of mediastinal thymoma were reviewed and relevant literature reviewed. Results Both patients were male, 35 and 38 years old, respectively. Histological manifestations of a typical biphasic performance, epithelial cells and spindle cells staggered distribution of interstitial scattered a small number of lymphocytes, tumor cells without significant atypia. Immunophenotype: Ckpan (+), CD5 (-), Vimentin (+), Ckpan (-) in the spindle cell region. Conclusions Metaphyseal thymoma is a rare tumor with histological morphology which is completely different from that of common thymoma. The tumor generally has no recurrence or metastasis and is a subtype of thymoma with low malignant potential.