论文部分内容阅读
目的:探讨妊娠期高血压综合征(妊高征)患者凝血四项指标及血小板(PLT)计数的变化及其临床意义。方法:检测120名正常非孕期妇女、120名中后期妊娠妇女和360例妊高征患者的血浆凝血酶原时间(PT)、国际标准化比值(INR)、活化部分凝血活酶时间(APTT)、纤维蛋白原(Fbg)、凝血酶时间(TT)和PLT,并进行统计学分析。结果:妊高征患者的凝血四项指标及PLT水平与正常非孕期妇女、正常妊娠妇女比较,差异有统计学意义,其PT、APTT、TT缩短,PLT减少尤为明显,且随着病情的加重而递减,Fbg含量则逐渐升高,使其处于严重的血栓前状态。结论:妊高征患者体内存在着凝血和纤溶系统的平衡紊乱,有血栓形成的趋向和危险,产前进行凝血四项和PLT检测可指导产科医师采取相应措施,在防治出血、避免弥散性血管内凝血(DIC)的发生和保障母婴安全等中具有重要的临床意义。
Objective: To investigate the changes and clinical significance of four indicators of coagulation and platelet count (PLT) in patients with gestational hypertension (PIH). Methods: The plasma prothrombin time (PT), international normalized ratio (INR), activated partial thromboplastin time (APTT), serum creatinine and total cholesterol in patients with normal pregnancy, 120 normal pregnant women and 360 pregnant women with PIH were measured. Fibrinogen (Fbg), thrombin time (TT) and PLT, and statistical analysis. Results: Compared with normal non-pregnant women and normal pregnant women, the four indicators of coagulation and PLT levels in patients with PIH were significantly different, PT, APTT, TT shortened, and PLT decreased especially with the increase of disease Declining, Fbg content is gradually increased, making it in a serious prethrombotic state. CONCLUSION: There is a balance disorder between coagulation and fibrinolytic system in patients with PIH. There are tendencies and risks of thrombosis. Prenatal coagulation and PLT can guide obstetricians to take corresponding measures to prevent bleeding and avoid disseminated The occurrence of intravascular coagulation (DIC) and the protection of maternal and infant safety have important clinical significance.